Crystal structures of highly simplified BPTIs provide insights into hydration-driven increase of unfolding enthalpy

We report a thermodynamic and structural analysis of six extensively simplified bovine pancreatic trypsin inhibitor (BPTI) variants containing 19–24 alanines out of 58 residues. Differential scanning calorimetry indicated a two-state thermal unfolding, typical of a native protein with densely packed...

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Detalles Bibliográficos
Autores principales: Islam, Mohammad Monirul, Yohda, Masafumi, Kidokoro, Shun-ichi, Kuroda, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339861/
https://www.ncbi.nlm.nih.gov/pubmed/28266637
http://dx.doi.org/10.1038/srep41205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339861/
https://www.ncbi.nlm.nih.gov/pubmed/28266637
http://dx.doi.org/10.1038/srep41205

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