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Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases
BACKGROUND: The production of β-lactamases by bacteria is the most common mechanism of resistance to the widely prescribed β-lactam antibiotics. β-lactamase inhibitory protein (BLIP) competitively inhibits class A β-lactamases via two binding loops that occlude the active site. It has been shown tha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340008/ https://www.ncbi.nlm.nih.gov/pubmed/28264645 http://dx.doi.org/10.1186/s12858-017-0077-1 |