Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

BACKGROUND: The complement cascade not only provides protection from infection but can also mediate destructive inflammation. Complement is also involved in elimination of neuronal synapses which is essential for proper development, but can be detrimental during aging and disease. C1q, required for...

Descripción completa

Detalles Bibliográficos
Autores principales: Fonseca, Maria I., Chu, Shu-Hui, Hernandez, Michael X., Fang, Melody J., Modarresi, Lila, Selvan, Pooja, MacGregor, Grant R., Tenner, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340039/
https://www.ncbi.nlm.nih.gov/pubmed/28264694
http://dx.doi.org/10.1186/s12974-017-0814-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340039/
https://www.ncbi.nlm.nih.gov/pubmed/28264694
http://dx.doi.org/10.1186/s12974-017-0814-9

Ejemplares similares