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Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain
BACKGROUND: The complement cascade not only provides protection from infection but can also mediate destructive inflammation. Complement is also involved in elimination of neuronal synapses which is essential for proper development, but can be detrimental during aging and disease. C1q, required for...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340039/ https://www.ncbi.nlm.nih.gov/pubmed/28264694 http://dx.doi.org/10.1186/s12974-017-0814-9 |