How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Efforts are underway to transform regulatory toxicology and chemical safety assessment from a largely empirical science based on direct observation of apical toxicity outcomes in whole organism toxicity tests to a predictive one in which outcomes and risk are inferred from accumulated mechanistic un...

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Detalles Bibliográficos
Autores principales: Wittwehr, Clemens, Aladjov, Hristo, Ankley, Gerald, Byrne, Hugh J., de Knecht, Joop, Heinzle, Elmar, Klambauer, Günter, Landesmann, Brigitte, Luijten, Mirjam, MacKay, Cameron, Maxwell, Gavin, Meek, M. E. (Bette), Paini, Alicia, Perkins, Edward, Sobanski, Tomasz, Villeneuve, Dan, Waters, Katrina M., Whelan, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Forum: AOPs, Computational Models, and Regulatory Toxicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340205/
https://www.ncbi.nlm.nih.gov/pubmed/27994170
http://dx.doi.org/10.1093/toxsci/kfw207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340205/
https://www.ncbi.nlm.nih.gov/pubmed/27994170
http://dx.doi.org/10.1093/toxsci/kfw207

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