Mitochondrial Lon is over-expressed in high-grade gliomas, and mediates hypoxic adaptation: potential role of Lon as a therapeutic target in glioma

Mitochondrial dysfunction is a hallmark of cancer biology. Tumor mitochondrial metabolism is characterized by an abnormal ability to function in scarce oxygen conditions through glycolysis (the Warburg effect), and accumulation of mitochondrial DNA defects are present in both hereditary neoplasia an...

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Detalles Bibliográficos
Autores principales: Di, Kaijun, Lomeli, Naomi, Wood, Spencer D., Vanderwal, Christopher D., Bota, Daniela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340227/
https://www.ncbi.nlm.nih.gov/pubmed/27764809
http://dx.doi.org/10.18632/oncotarget.12681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340227/
https://www.ncbi.nlm.nih.gov/pubmed/27764809
http://dx.doi.org/10.18632/oncotarget.12681

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