Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes

Metabolic reprogramming has been described as a hallmark of transformed cancer cells. In this study, we examined the role of the glutamine (Gln) utilization pathway in acute myeloid leukemia (AML) cell lines and primary AML samples. Our results indicate that a subset of AML cell lines is sensitive t...

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Detalles Bibliográficos
Autores principales: Matre, Polina, Velez, Juliana, Jacamo, Rodrigo, Qi, Yuan, Su, Xiaoping, Cai, Tianyu, Chan, Steven M., Lodi, Alessia, Sweeney, Shannon R., Ma, Helen, Davis, Richard Eric, Baran, Natalia, Haferlach, Torsten, Su, Xiaohua, Flores, Elsa Renee, Gonzalez, Doriann, Konoplev, Sergej, Samudio, Ismael, DiNardo, Courtney, Majeti, Ravi, Schimmer, Aaron D., Li, Weiqun, Wang, Taotao, Tiziani, Stefano, Konopleva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340236/
https://www.ncbi.nlm.nih.gov/pubmed/27806325
http://dx.doi.org/10.18632/oncotarget.12944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340236/
https://www.ncbi.nlm.nih.gov/pubmed/27806325
http://dx.doi.org/10.18632/oncotarget.12944

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