SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status

The observation that cellular transformation depends on breaching a crucial KRAS activity threshold, along with the finding that only a small percentage of cellsharboring KRAS mutations are transformed, support the idea that additional, not fully uncovered, regulatory mechanisms may contribute to KR...

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Detalles Bibliográficos
Autores principales: Song, Ha Yong, Biancucci, Marco, Kang, Hong-Jun, O'Callaghan, Carol, Park, Seong-Hoon, Principe, Daniel R., Jiang, Haiyan, Yan, Yufan, Satchell, Karla Fullner, Raparia, Kirtee, Gius, David, Vassilopoulos, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340253/
https://www.ncbi.nlm.nih.gov/pubmed/27637077
http://dx.doi.org/10.18632/oncotarget.12015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340253/
https://www.ncbi.nlm.nih.gov/pubmed/27637077
http://dx.doi.org/10.18632/oncotarget.12015

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