Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

The target of rapamycin (TOR) protein kinase forms multi-subunit TOR complex 1 (TORC1) and TOR complex 2 (TORC2), which exhibit distinct substrate specificities. Sin1 is one of the TORC2-specific subunit essential for phosphorylation and activation of certain AGC-family kinases. Here, we show that S...

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Detalles Bibliográficos
Autores principales: Tatebe, Hisashi, Murayama, Shinichi, Yonekura, Toshiya, Hatano, Tomoyuki, Richter, David, Furuya, Tomomi, Kataoka, Saori, Furuita, Kyoko, Kojima, Chojiro, Shiozaki, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340527/
https://www.ncbi.nlm.nih.gov/pubmed/28264193
http://dx.doi.org/10.7554/eLife.19594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340527/
https://www.ncbi.nlm.nih.gov/pubmed/28264193
http://dx.doi.org/10.7554/eLife.19594

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