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Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

The target of rapamycin (TOR) protein kinase forms multi-subunit TOR complex 1 (TORC1) and TOR complex 2 (TORC2), which exhibit distinct substrate specificities. Sin1 is one of the TORC2-specific subunit essential for phosphorylation and activation of certain AGC-family kinases. Here, we show that S...

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Detalles Bibliográficos
Autores principales:	Tatebe, Hisashi, Murayama, Shinichi, Yonekura, Toshiya, Hatano, Tomoyuki, Richter, David, Furuya, Tomomi, Kataoka, Saori, Furuita, Kyoko, Kojima, Chojiro, Shiozaki, Kazuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340527/ https://www.ncbi.nlm.nih.gov/pubmed/28264193 http://dx.doi.org/10.7554/eLife.19594

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