YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

The ubiquitin ligase TRAF6 is a key regulator of canonical IκB kinase (IKK)/NF-κB signaling in response to interleukin-1 (IL-1) stimulation. Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interactor of TRAF6 in human cells. YOD1 binds to the C-terminal TRAF homology domain o...

Descripción completa

Detalles Bibliográficos
Autores principales: Schimmack, Gisela, Schorpp, Kenji, Kutzner, Kerstin, Gehring, Torben, Brenke, Jara Kerstin, Hadian, Kamyar, Krappmann, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340530/
https://www.ncbi.nlm.nih.gov/pubmed/28244869
http://dx.doi.org/10.7554/eLife.22416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340530/
https://www.ncbi.nlm.nih.gov/pubmed/28244869
http://dx.doi.org/10.7554/eLife.22416

Ejemplares similares