Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ

Emerging evidence indicates that human cytomegalovirus (HCMV) manipulates host cell signaling pathways using both proteins and noncoding RNAs. Several studies have shown that HCMV induces NF-κB signaling early in infection, resulting in the induction of antiviral proinflammatory cytokines with a sub...

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Detalles Bibliográficos
Autores principales: Hancock, Meaghan H., Hook, Lauren M., Mitchell, Jennifer, Nelson, Jay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340867/
https://www.ncbi.nlm.nih.gov/pubmed/28270578
http://dx.doi.org/10.1128/mBio.00109-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340867/
https://www.ncbi.nlm.nih.gov/pubmed/28270578
http://dx.doi.org/10.1128/mBio.00109-17

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