Mutations of EXOSC3/Rrp40p associated with neurological diseases impact ribosomal RNA processing functions of the exosome in S. cerevisiae

The RNA exosome is a conserved multiprotein complex that achieves a large number of processive and degradative functions in eukaryotic cells. Recently, mutations have been mapped to the gene encoding one of the subunits of the exosome, EXOSC3 (yeast Rrp40p), which results in pontocerebellar hypoplas...

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Detalles Bibliográficos
Autores principales: Gillespie, Abby, Gabunilas, Jason, Jen, Joanna C., Chanfreau, Guillaume F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340910/
https://www.ncbi.nlm.nih.gov/pubmed/28053271
http://dx.doi.org/10.1261/rna.060004.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340910/
https://www.ncbi.nlm.nih.gov/pubmed/28053271
http://dx.doi.org/10.1261/rna.060004.116

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