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A central role of Cwc25 in spliceosome dynamics during the catalytic phase of pre-mRNA splicing
Splicing of precursor mRNA occurs via two consecutive steps of transesterification reaction; both require ATP and several proteins. Despite the energy requirement in the catalytic phase, incubation of the purified spliceosome under proper ionic conditions can elicit competitive reversible transester...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340917/ https://www.ncbi.nlm.nih.gov/pubmed/28057857 http://dx.doi.org/10.1261/rna.059204.116 |