Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution

Mitochondrial DNA (mtDNA) genes are long known to be cotranscribed in polycistrones, yet it remains impossible to study nascent mtDNA transcripts quantitatively in vivo using existing tools. To this end, we used deep sequencing (GRO-seq and PRO-seq) and analyzed nascent mtDNA-encoded RNA transcripts...

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Detalles Bibliográficos
Autores principales: Blumberg, Amit, Rice, Edward J., Kundaje, Anshul, Danko, Charles G., Mishmar, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340964/
https://www.ncbi.nlm.nih.gov/pubmed/28049628
http://dx.doi.org/10.1101/gr.209924.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340964/
https://www.ncbi.nlm.nih.gov/pubmed/28049628
http://dx.doi.org/10.1101/gr.209924.116

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