A GC-rich sequence feature in the 3′ UTR directs UPF1-dependent mRNA decay in mammalian cells

Up-frameshift protein 1 (UPF1) is an ATP-dependent RNA helicase that has essential roles in RNA surveillance and in post-transcriptional gene regulation by promoting the degradation of mRNAs. Previous studies revealed that UPF1 is associated with the 3′ untranslated region (UTR) of target mRNAs via...

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Detalles Bibliográficos
Autores principales: Imamachi, Naoto, Salam, Kazi Abdus, Suzuki, Yutaka, Akimitsu, Nobuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340968/
https://www.ncbi.nlm.nih.gov/pubmed/27940950
http://dx.doi.org/10.1101/gr.206060.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340968/
https://www.ncbi.nlm.nih.gov/pubmed/27940950
http://dx.doi.org/10.1101/gr.206060.116

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