Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes

Understanding how regulatory sequences interact in the context of chromosomal architecture is a central challenge in biology. Chromosome conformation capture revealed that mammalian chromosomes possess a rich hierarchy of structural layers, from multi-megabase compartments to sub-megabase topologica...

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Detalles Bibliográficos
Autores principales: Zhan, Yinxiu, Mariani, Luca, Barozzi, Iros, Schulz, Edda G., Blüthgen, Nils, Stadler, Michael, Tiana, Guido, Giorgetti, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340975/
https://www.ncbi.nlm.nih.gov/pubmed/28057745
http://dx.doi.org/10.1101/gr.212803.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340975/
https://www.ncbi.nlm.nih.gov/pubmed/28057745
http://dx.doi.org/10.1101/gr.212803.116

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