Investigations on Binding Pattern of Kinase Inhibitors with PPARγ: Molecular Docking, Molecular Dynamic Simulations, and Free Energy Calculation Studies

Peroxisome proliferator-activated receptor gamma (PPARγ) is a potential target for the treatment of several disorders. In view of several FDA approved kinase inhibitors, in the current study, we have investigated the interaction of selected kinase inhibitors with PPARγ using computational modeling,...

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Detalles Bibliográficos
Autores principales: Mazumder, Mohit, Ponnan, Prija, Das, Umashankar, Gourinath, Samudrala, Khan, Haseeb Ahmad, Yang, Jian, Sakharkar, Meena Kishore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340984/
https://www.ncbi.nlm.nih.gov/pubmed/28321247
http://dx.doi.org/10.1155/2017/6397836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340984/
https://www.ncbi.nlm.nih.gov/pubmed/28321247
http://dx.doi.org/10.1155/2017/6397836

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