Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue

According to clinical data, some tyrosine kinase inhibitors (TKIs) possess antidiabetic effects. Several proposed mechanisms were assigned to them, however their mode of action is not clear. Our hypothesis was that they directly stimulate insulin release in beta cells. In our screening approach we d...

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Detalles Bibliográficos
Autores principales: Orfi, Z., Waczek, F., Baska, F., Szabadkai, I., Torka, R., Hartmann, J., Orfi, L., Ullrich, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341024/
https://www.ncbi.nlm.nih.gov/pubmed/28272433
http://dx.doi.org/10.1038/srep44073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341024/
https://www.ncbi.nlm.nih.gov/pubmed/28272433
http://dx.doi.org/10.1038/srep44073

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