Melanosomal formation of PMEL core amyloid is driven by aromatic residues

PMEL is a pigment cell protein that forms physiological amyloid in melanosomes. Many amyloids and/or their oligomeric precursors are toxic, causing or contributing to severe, incurable diseases including Alzheimer’s and prion diseases. Striking similarities in intracellular formation pathways betwee...

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Detalles Bibliográficos
Autores principales: Hee, Jia Shee, Mitchell, Susan M., Liu, Xinran, Leonhardt, Ralf M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341037/
https://www.ncbi.nlm.nih.gov/pubmed/28272432
http://dx.doi.org/10.1038/srep44064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341037/
https://www.ncbi.nlm.nih.gov/pubmed/28272432
http://dx.doi.org/10.1038/srep44064

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