Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol

LAT1 (SLC7A5) is a transporter for both the uptake of large neutral amino acids and a number of pharmaceutical drugs. It is expressed in numerous cell types including T-cells, cancer cells and brain endothelial cells. However, mechanistic knowledge of how it functions and its interactions with lipid...

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Detalles Bibliográficos
Autores principales: Dickens, David, Chiduza, George N., Wright, Gareth S. A., Pirmohamed, Munir, Antonyuk, Svetlana V., Hasnain, S. Samar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341093/
https://www.ncbi.nlm.nih.gov/pubmed/28272458
http://dx.doi.org/10.1038/srep43580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341093/
https://www.ncbi.nlm.nih.gov/pubmed/28272458
http://dx.doi.org/10.1038/srep43580

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