Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly

Recessive mutations in WD repeat domain 62 (WDR62) cause microcephaly and a wide spectrum of severe brain malformations. Disruption of the mouse ortholog results in microcephaly underlain by reduced proliferation of neocortical progenitors during late neurogenesis, abnormalities in asymmetric centro...

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Detalles Bibliográficos
Autores principales: Sgourdou, Paraskevi, Mishra-Gorur, Ketu, Saotome, Ichiko, Henagariu, Octavian, Tuysuz, Beyhan, Campos, Cynthia, Ishigame, Keiko, Giannikou, Krinio, Quon, Jennifer L., Sestan, Nenad, Caglayan, Ahmet O., Gunel, Murat, Louvi, Angeliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341122/
https://www.ncbi.nlm.nih.gov/pubmed/28272472
http://dx.doi.org/10.1038/srep43708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341122/
https://www.ncbi.nlm.nih.gov/pubmed/28272472
http://dx.doi.org/10.1038/srep43708

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