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Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction
Cu(i) carbenes derived from α-diazocarbonyl compounds lead to selective alkylation of the O(6) position in guanine (O(6)-G) in mono- and oligonucleotides. Only purine-type lactam oxygens are targeted – other types of amides or lactams are poorly reactive under conditions that give smooth alkylation...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341205/ https://www.ncbi.nlm.nih.gov/pubmed/28451197 http://dx.doi.org/10.1039/c6sc03502g |