Cargando…

Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction

Cu(i) carbenes derived from α-diazocarbonyl compounds lead to selective alkylation of the O(6) position in guanine (O(6)-G) in mono- and oligonucleotides. Only purine-type lactam oxygens are targeted – other types of amides or lactams are poorly reactive under conditions that give smooth alkylation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geigle, Stefanie N., Wyss, Laura A., Sturla, Shana J., Gillingham, Dennis G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341205/ https://www.ncbi.nlm.nih.gov/pubmed/28451197 http://dx.doi.org/10.1039/c6sc03502g

Ejemplares similares

The influence of alkyl chains on the performance of DSCs employing iron(ii) N-heterocyclic carbene sensitizers
por: Becker, Mariia, et al.
Publicado: (2021)

Copper-catalyzed direct alkylation of heteroarenes
por: Theunissen, Cédric, et al.
Publicado: (2017)

Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation
por: Shi, Xiaodong, et al.
Publicado: (2018)

Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
por: Lu, Jiaqing, et al.
Publicado: (2019)

Enantioselective N-heterocyclic carbene-catalyzed nucleophilic dearomatization of alkyl pyridiniums
por: Flanigan, Darrin M., et al.
Publicado: (2017)

The debut of chiral cyclic (alkyl)(amino)carbenes (CAACs) in enantioselective catalysis
por: Pichon, Delphine, et al.
Publicado: (2019)

Gold-catalyzed (4 + 2)-annulations between α-alkyl alkenylgold carbenes and benzisoxazoles with reactive alkyl groups
por: Mokar, Bhanudas Dattatray, et al.
Publicado: (2018)

Uncommon carbene insertion reactions
por: Huang, Ming-Yao, et al.
Publicado: (2021)

Carbene-catalyzed chemoselective reaction of unsymmetric enedials for access to Furo[2,3-b]pyrroles
por: Fan, Guodong, et al.
Publicado: (2023)

Heme compound II models in chemoselectivity and disproportionation reactions
por: Gupta, Ranjana, et al.
Publicado: (2022)

Stable cyclic (alkyl)(amino)carbene (cAAC) radicals with main group substituents
por: Kundu, Subrata, et al.
Publicado: (2019)

Rhodium‐Catalyzed C−H Methylation and Alkylation Reactions by Carbene‐Transfer Reactions
por: Empel, Claire, et al.
Publicado: (2022)

Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media
por: Khademi, Zahra, et al.
Publicado: (2020)

Cr(i)Cl as well as Cr(+) are stabilised between two cyclic alkyl amino carbenes
por: Samuel, Prinson P., et al.
Publicado: (2015)

Molecular beacons with oxidized bases report on substrate specificity of DNA oxoguanine glycosylases
por: Sun, Jingjing, et al.
Publicado: (2022)

Chemoselective synthesis of multifunctional ferrocene-containing derivatives by the cross Rauhut–Currier reaction
por: Stevanović, Dragana, et al.
Publicado: (2021)

C−X (X = N, O) Cross-Coupling Reactions Catalyzed by Copper-Pincer Bis(N-Heterocyclic Carbene) Complexes
por: Minnick, Jennifer L., et al.
Publicado: (2019)

Nickel-catalyzed migratory alkyl–alkyl cross-coupling reaction
por: Li, Yangyang, et al.
Publicado: (2020)

Catalytic asymmetric direct aldol reaction of α-alkyl azlactones and aliphatic aldehydes
por: Zheng, Yang, et al.
Publicado: (2015)

Chemoselectivity in Gold(I)-Catalyzed Propargyl Ester Reactions: Insights From DFT Calculations
por: Sun, Qing, et al.
Publicado: (2019)

Torsional strain inversed chemoselectivity in a Pd-catalyzed atroposelective carbonylation reaction of dibenzothiophenium
por: Zhang, Qiuchi, et al.
Publicado: (2022)

Chemoselective Nozaki–Hiyama–Takai–Kishi and Grignard reaction: short synthesis of some carbahexopyranoses
por: Vinaykumar, Allam, et al.
Publicado: (2023)

Chemoselective carbene insertion into the N−H bonds of NH(3)·H(2)O
por: Liu, Zhaohong, et al.
Publicado: (2022)

The reaction of rhenium nitrosyl with a sterically hindered NHC-carbene
por: Grieco, G., et al.
Publicado: (2022)

Highly photoluminescent copper carbene complexes based on prompt rather than delayed fluorescence
por: Romanov, Alexander S., et al.
Publicado: (2016)

Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation
por: Montoir, David, et al.
Publicado: (2018)

Bis(imino)pyridine iron complexes for catalytic carbene transfer reactions
por: Wang, Ban, et al.
Publicado: (2019)

Direct access to 2-aryl substituted pyrrolinium salts for carbon centre based radicals without pyrrolidine-2-ylidene alias cyclic(alkyl)(amino)carbene (CAAC) as a precursor
por: Mandal, Debdeep, et al.
Publicado: (2019)

Recent Advances in the Domain of Cyclic (Alkyl)(Amino) Carbenes
por: Kumar Kushvaha, Saroj, et al.
Publicado: (2022)

Correction: Highly photoluminescent copper carbene complexes based on prompt rather than delayed fluorescence
por: Romanov, Alexander S., et al.
Publicado: (2018)

Photoinduced C(sp(3))–H sulfination empowers the direct and chemoselective introduction of the sulfonyl group
por: Jin, Shengfei, et al.
Publicado: (2021)

Electronic interactions between a stable electride and a nano-alloy control the chemoselective reduction reaction
por: Ye, Tian-Nan, et al.
Publicado: (2016)

Catalyst-Dependent Chemoselectivity in the Dirhodium-Catalyzed Cyclization Reactions Between Enodiazoacetamide and Nitrosoarene: A Theoretical Study
por: Zhang, Yan, et al.
Publicado: (2019)

DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters
por: Heo, Yu Jin, et al.
Publicado: (2021)

Soluble, crystalline, and thermally stable alkali CO(2)(−) and carbonite (CO(2)(2−)) clusters supported by cyclic(alkyl)(amino) carbenes
por: Freeman, Lucas A., et al.
Publicado: (2021)

Bicyclic (alkyl)(amino)carbene (BICAAC) in a dual role: activation of primary amides and CO(2) towards catalytic N-methylation
por: Gautam, Nimisha, et al.
Publicado: (2023)

Highly effective and chemoselective hydrodeoxygenation of aromatic alcohols
por: Xu, Caiyun, et al.
Publicado: (2022)

SET processes in Lewis acid–base reactions: the tritylation of N-heterocyclic carbenes
por: Dong, Zhaowen, et al.
Publicado: (2020)

Palladium-catalyzed chemoselective direct α-arylation of carbonyl compounds with chloroaryl triflates at the C–Cl site
por: Chen, Zicong, et al.
Publicado: (2022)

Alkylboronic acids as alkylating agents: photoredox-catalyzed alkylation reactions assisted by K(3)PO(4)
por: Yue, Fuyang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_104ckqi31rb579el6gl09sd1fq