An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

The G‐protein‐coupled receptor kinase 2 (adrbk2/GRK2) has been implicated in vertebrate Hedgehog (Hh) signalling based on the effects of its transient knock‐down in mammalian cells and zebrafish embryos. Here, we show that the response to Hh signalling is effectively abolished in the absence of Grk2...

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Detalles Bibliográficos
Autores principales: Zhao, Zhonghua, Lee, Raymond Teck Ho, Pusapati, Ganesh V, Iyu, Audrey, Rohatgi, Rajat, Ingham, Philip W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341524/
https://www.ncbi.nlm.nih.gov/pubmed/27113758
http://dx.doi.org/10.15252/embr.201541532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341524/
https://www.ncbi.nlm.nih.gov/pubmed/27113758
http://dx.doi.org/10.15252/embr.201541532

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