Structure-Activity Relationship in TLR4 Mutations: Atomistic Molecular Dynamics Simulations and Residue Interaction Network Analysis

Toll-like receptor 4 (TLR4), a vital innate immune receptor present on cell surfaces, initiates a signaling cascade during danger and bacterial intrusion. TLR4 needs to form a stable hexamer complex, which is necessary to dimerize the cytoplasmic domain. However, D299G and T399I polymorphism may abr...

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Detalles Bibliográficos
Autores principales: Anwar, Muhammad Ayaz, Choi, Sangdun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341570/
https://www.ncbi.nlm.nih.gov/pubmed/28272553
http://dx.doi.org/10.1038/srep43807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341570/
https://www.ncbi.nlm.nih.gov/pubmed/28272553
http://dx.doi.org/10.1038/srep43807

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