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C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity
ATP8A2 is a P4-ATPase that flips phosphatidylserine and phosphatidylethanolamine across cell membranes. This generates membrane phospholipid asymmetry, a property important in many cellular processes, including vesicle trafficking. ATP8A2 deficiency causes severe neurodegenerative diseases. We inves...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The American Society for Cell Biology
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341728/ https://www.ncbi.nlm.nih.gov/pubmed/27932490 http://dx.doi.org/10.1091/mbc.E16-06-0453 |