HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth

To cope with proteotoxic stress, cells attenuate protein synthesis. However, the precise mechanisms underlying this fundamental adaptation remain poorly defined. Here we report that mTORC1 acts as an immediate cellular sensor of proteotoxic stress. Surprisingly, the multifaceted stress-responsive ki...

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Detalles Bibliográficos
Autores principales: Su, Kuo-Hui, Cao, Junyue, Tang, Zijian, Dai, Siyuan, He, Yishu, Sampson, Stephen Byers, Benjamin, Ivor J., Dai, Chengkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341796/
https://www.ncbi.nlm.nih.gov/pubmed/27043084
http://dx.doi.org/10.1038/ncb3335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341796/
https://www.ncbi.nlm.nih.gov/pubmed/27043084
http://dx.doi.org/10.1038/ncb3335

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