PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity

Acute promyelocitic leukemia (APL) is characterized by the pathognomonic presence in leukemic blasts of the hybrid protein PML/RARA, that acts as a transcriptional repressor impairing the expression of genes that are critical to myeloid differentiation. Here, we show that primary blasts from APL pat...

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Detalles Bibliográficos
Autores principales: Noguera, Nélida Inés, Piredda, Maria Liliana, Taulli, Riccardo, Catalano, Gianfranco, Angelini, Giulia, Gaur, Girish, Nervi, Clara, Voso, Maria Teresa, Lunardi, Andrea, Pandolfi, Pier Paolo, Lo-Coco, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341808/
https://www.ncbi.nlm.nih.gov/pubmed/27626703
http://dx.doi.org/10.18632/oncotarget.11964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341808/
https://www.ncbi.nlm.nih.gov/pubmed/27626703
http://dx.doi.org/10.18632/oncotarget.11964

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