Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDR

P53 is frequently mutated in human tumors as a novel gain-of-function to promote tumor development. Although dimeric (M340Q/L344R) influences on tetramerisation on site-specific post-translational modifications of p53, it is not clear how dimeric (M340Q/L344R) plays a role during hepatocarcinogenesi...

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Detalles Bibliográficos
Autores principales: Wu, Mengying, An, Jiahui, Zheng, Qidi, Xin, Xiaoru, Lin, Zhuojia, Li, Xiaonan, Li, Haiyan, Lu, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341818/
https://www.ncbi.nlm.nih.gov/pubmed/27167190
http://dx.doi.org/10.18632/oncotarget.9089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341818/
https://www.ncbi.nlm.nih.gov/pubmed/27167190
http://dx.doi.org/10.18632/oncotarget.9089

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