Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer

The mechanistic target of rapamycin (mTOR) is a rational target for cancer treatment. While the mTORC1-selective rapalogs have shown significant benefits in the clinic, antitumor response may be further improved by inhibiting both mTORC1 and mTORC2. Herein, we established target profile of a novel m...

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Detalles Bibliográficos
Autores principales: Qian, Jianchang, Chen, Yaqing, Meng, Tao, Ma, Lanping, Meng, Lanfang, Wang, Xin, Yu, Ting, Zask, Arie, Shen, Jingkang, Yu, Ker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341858/
https://www.ncbi.nlm.nih.gov/pubmed/27563814
http://dx.doi.org/10.18632/oncotarget.11490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341858/
https://www.ncbi.nlm.nih.gov/pubmed/27563814
http://dx.doi.org/10.18632/oncotarget.11490

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