Cargando…

Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells

Glucorticoids (GCs) such as dexamethasone (DEX) remain important treatments for Chronic Lymphocytic Leukemia (CLL) but the mechanisms are poorly understood and resistance is inevitable. Proliferation centers (PC) in lymph nodes and bone marrow offer protection against many cytotoxic drugs and circul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oppermann, Sina, Lam, Avery J., Tung, Stephanie, Shi, Yonghong, McCaw, Lindsay, Wang, Guizhei, Ylanko, Jarkko, Leber, Brian, Andrews, David, Spaner, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341931/ https://www.ncbi.nlm.nih.gov/pubmed/27579615 http://dx.doi.org/10.18632/oncotarget.11618

Ejemplares similares

Persistent janus kinase‐signaling in chronic lymphocytic leukemia patients on ibrutinib: Results of a phase I trial
por: Spaner, David E., et al.
Publicado: (2019)

Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial
por: Spaner, David E., et al.
Publicado: (2021)

Low Density Lipoproteins Amplify Cytokine-signaling in Chronic Lymphocytic Leukemia Cells
por: McCaw, Lindsay, et al.
Publicado: (2016)

A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis
por: Collins, Tony J., et al.
Publicado: (2015)

Janus Kinases in Leukemia
por: Raivola, Juuli, et al.
Publicado: (2021)

Image‐Based Analysis of Protein Stability
por: Hickman, K. Ashley, et al.
Publicado: (2019)

Janus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors
por: Cerquone Perpetuini, Andrea, et al.
Publicado: (2020)

O-GlcNAcylation in Chronic Lymphocytic Leukemia and Other Blood Cancers
por: Spaner, David E.
Publicado: (2021)

Janus kinase inhibitors for the therapy of atopic dermatitis
por: Traidl, Stephan, et al.
Publicado: (2021)

Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo
por: Spaner, David E., et al.
Publicado: (2023)

miRNA‐106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation
por: Hoey, Christianne, et al.
Publicado: (2018)

Association of blood IgG with tumor necrosis factor-alpha and clinical course of chronic lymphocytic leukemia
por: Spaner, David E., et al.
Publicado: (2018)

Impact of Emerging Antiviral Drug Resistance on Influenza Containment and Spread: Influence of Subclinical Infection and Strategic Use of a Stockpile Containing One or Two Drugs
por: McCaw, James M., et al.
Publicado: (2008)

A Synopsis of the History of Dermatology
por: McCaw, Ivan H.
Publicado: (1944)

Infections of the Beard Region
por: McCaw, Ivan H.
Publicado: (1932)

Deathless Midwifery—An Obstetric Record
por: McCaw, J. Dysart
Publicado: (1897)

A Case of Uterine Hydatids
por: McCaw, James B.
Publicado: (1858)

Both Drosophila matrix metalloproteinases have released and membrane-tethered forms but have different substrates
por: LaFever, Kimberly S., et al.
Publicado: (2017)

A Biological Model for Influenza Transmission: Pandemic Planning Implications of Asymptomatic Infection and Immunity
por: Mathews, John D., et al.
Publicado: (2007)

Janus kinase 2 regulates Bcr–Abl signaling in chronic myeloid leukemia
por: Samanta, A, et al.
Publicado: (2011)

The Janus kinases (Jaks)
por: Yamaoka, Kunihiro, et al.
Publicado: (2004)

A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation
por: Wang, Xiaoxi, et al.
Publicado: (2014)

Wnt Signaling in Stem Cell Maintenance and Differentiation in the Drosophila Germarium
por: Waghmare, Indrayani, et al.
Publicado: (2018)

The Mechanisms for Within-Host Influenza Virus Control Affect Model-Based Assessment and Prediction of Antiviral Treatment
por: Cao, Pengxing, et al.
Publicado: (2017)

Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche
por: Wang, Xiaoxi, et al.
Publicado: (2018)

Glypicans and cytonemes unite to distribute Wnt ligands
por: Waghmare, Indrayani, et al.
Publicado: (2021)

Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations
por: Senkevitch, Emilee, et al.
Publicado: (2018)

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia
por: Silveira, André Bortolini, et al.
Publicado: (2015)

Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape
por: Farhy, Chen, et al.
Publicado: (2019)

Emerging Role of Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis
por: Singh, Rhea, et al.
Publicado: (2020)

A secreted MMP is required for reepithelialization during wound healing
por: Stevens, Laura J., et al.
Publicado: (2012)

Itch and Janus Kinase Inhibitors
por: HAN, Yujin, et al.
Publicado: (2023)

Bullous pemphigoid treated with Janus kinase inhibitor upadacitinib
por: Nash, David, et al.
Publicado: (2022)

Retardation of Division of Three Ciliates by Intermittent and Continuous Ultraviolet Radiations at Different Temperatures
por: Giese, A. C., et al.
Publicado: (1963)

Kctd12 and Ulk2 Partner to Regulate Dendritogenesis and Behavior in the Habenular Nuclei
por: Lee, Stacey, et al.
Publicado: (2014)

Model answers or trivial pursuits? The role of mathematical models in influenza pandemic preparedness planning
por: McVernon, J, et al.
Publicado: (2007)

FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation
por: Li, Mingyu, et al.
Publicado: (2016)

Modelling the Effect of MUC1 on Influenza Virus Infection Kinetics and Macrophage Dynamics
por: Li, Ke, et al.
Publicado: (2021)

Fitting Gaussian mixture models on incomplete data
por: McCaw, Zachary R., et al.
Publicado: (2022)

Correction: Fitting Gaussian mixture models on incomplete data
por: McCaw, Zachary R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nloe6iolguf32diffi4fhjcpbr