Cargando…

Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability

The moderate anticancer effect of arginine deprivation in clinical trials has been linked to an induced argininosuccinate synthetase (ASS1) expression in initially ASS1-negative tumors, and ASS1-positive cancers are anticipated as non-responders. Our previous studies indicated that arginine deprivat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kurlishchuk, Yuliya, Vynnytska-Myronovska, Bozhena, Grosse-Gehling, Philipp, Bobak, Yaroslav, Manig, Friederike, Chen, Oleg, Merker, Sebastian R., Henle, Thomas, Löck, Steffen, Stange, Daniel E., Stasyk, Oleh, Kunz, Leoni A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341980/ https://www.ncbi.nlm.nih.gov/pubmed/27689335 http://dx.doi.org/10.18632/oncotarget.12320

Ejemplares similares

Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms
por: Karatsai, Olena, et al.
Publicado: (2020)

An In Vitro Analysis of TKI-Based Sequence Therapy in Renal Cell Carcinoma Cell Lines
por: Zaccagnino, Angela, et al.
Publicado: (2023)

Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3
por: Shuvayeva, Galyna, et al.
Publicado: (2014)

Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells
por: Chen, Oleg, et al.
Publicado: (2020)

L-Canavanine potentiates the cytotoxicity of doxorubicin and cisplatin in arginine deprived human cancer cells
por: Nurcahyanti, Agustina DR, et al.
Publicado: (2016)

Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation
por: Pavlyk, Iuliia, et al.
Publicado: (2014)

Cyanamide is biosynthesized from l-canavanine in plants
por: Kamo, Tsunashi, et al.
Publicado: (2015)

Arginine and Citrulline and the Immune Response in Sepsis
por: Wijnands, Karolina A.P., et al.
Publicado: (2015)

Gαo Is Required for L-Canavanine Detection in Drosophila
por: Devambez, Isabelle, et al.
Publicado: (2013)

Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe
por: Pai, Chen-Chun, et al.
Publicado: (2023)

Protein Arginine Methylation and Citrullination in Epigenetic Regulation
por: Fuhrmann, Jakob, et al.
Publicado: (2015)

Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence
por: Tsuboi, Tomoe, et al.
Publicado: (2018)

Canavanine inhibits vimentin assembly but not its synthesis in chicken embryo erythroid cells
Publicado: (1983)

Canavanine Increases the Content of Phenolic Compounds in Tomato (Solanum lycopersicum L.) Roots
por: Staszek, Pawel, et al.
Publicado: (2020)

The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin
por: Lam van, Thuy Van, et al.
Publicado: (2021)

Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer
por: Beato, Miguel, et al.
Publicado: (2020)

The effect of citrulline and arginine supplementation on lactic acidemia in MELAS syndrome()
por: El-Hattab, Ayman W., et al.
Publicado: (2013)

Joint inflammation related citrullination of functional arginines in extracellular proteins
por: Sipilä, Kalle H., et al.
Publicado: (2017)

Nitric Oxide Deficiency in Mitochondrial Disorders: The Utility of Arginine and Citrulline
por: Almannai, Mohammed, et al.
Publicado: (2021)

The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure
por: Khalaf, David, et al.
Publicado: (2019)

Modification of substrate specificity of l-arginine oxidase for detection of l-citrulline
por: Yamamoto, Kei, et al.
Publicado: (2023)

Canavanine-induced longevity in mice may require diets with greater than 15.7% protein
por: Brown, Dan L
Publicado: (2005)

Plant Insecticide L-Canavanine Repels Drosophila via the Insect Orphan GPCR DmX
por: Mitri, Christian, et al.
Publicado: (2009)

Canavanine utilization via homoserine and hydroxyguanidine by a PLP-dependent γ-lyase in Pseudomonadaceae and Rhizobiales
por: Hauth, Franziskus, et al.
Publicado: (2022)

A comparison of citrulline and arginine for increasing exercise-induced vasodilation and blood flow
por: Moon, Jordan R, et al.
Publicado: (2015)

Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination
por: Nagar, Mitesh, et al.
Publicado: (2019)

Endothelial Dysfunction and the Effect of Arginine and Citrulline Supplementation in Children and Adolescents With Mitochondrial Diseases
por: Al Jasmi, Fatma, et al.
Publicado: (2020)

Quantitation of free glycation compounds in saliva
por: Manig, Friederike, et al.
Publicado: (2019)

Studies about the Dietary Impact on “Free” Glycation Compounds in Human Saliva
por: Manig, Friederike, et al.
Publicado: (2022)

Effects of arginine replacement with L-citrulline on the arginine/nitric oxide metabolism in chickens: An animal model without urea cycle
por: Uyanga, Victoria Anthony, et al.
Publicado: (2023)

Binding ability of arginine, citrulline, N-acetyl citrulline and thiocitrulline with SARS COV-2 main protease using molecular docking studies
por: Thimmasandra Narayan, Ramesh
Publicado: (2021)

Canavanine Alters ROS/RNS Level and Leads to Post-translational Modification of Proteins in Roots of Tomato Seedlings
por: Krasuska, Urszula, et al.
Publicado: (2016)

Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape
por: Infield, Daniel T., et al.
Publicado: (2018)

Fruit Morphology, Citrulline, and Arginine Levels in Diverse Watermelon (Citrullus lanatus) Germplasm Collections
por: Assefa, Awraris Derbie, et al.
Publicado: (2020)

Dietary Arginine and Citrulline Supplements for Cardiovascular Health and Athletic Performance: A Narrative Review
por: Park, Hun-Young, et al.
Publicado: (2023)

A standalone editing protein deacylates mischarged canavanyl-tRNA(Arg) to prevent canavanine incorporation into proteins
por: Hauth, Franziskus, et al.
Publicado: (2023)

The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules
por: Kampstra, Arieke S. B., et al.
Publicado: (2016)

Citrulline a More Suitable Substrate than Arginine to Restore NO Production and the Microcirculation during Endotoxemia
por: Wijnands, Karolina A. P., et al.
Publicado: (2012)

Citrulline Supplementation Improves Organ Perfusion and Arginine Availability under Conditions with Enhanced Arginase Activity
por: Wijnands, Karolina A.P., et al.
Publicado: (2015)

Development of Isocratic RP-HPLC Method for Separation and Quantification of L-Citrulline and L-Arginine in Watermelons
por: Ridwan, Rasdin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dq2rm5ivgmvvdl2143r4mn6vu7