Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients

Overexpression of ABCB1, ABCC1 and ABCG2 in tumor tissues is considered a major cause of limited efficacy of anticancer drugs. Gene expression of ABC transporters is regulated by multiple mechanisms, including changes in the DNA methylation status. Most of the studies published so far only report pr...

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Detalles Bibliográficos
Autores principales: Spitzwieser, Melanie, Pirker, Christine, Koblmüller, Bettina, Pfeiler, Georg, Hacker, Stefan, Berger, Walter, Heffeter, Petra, Cichna-Markl, Margit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341984/
https://www.ncbi.nlm.nih.gov/pubmed/27689338
http://dx.doi.org/10.18632/oncotarget.12332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341984/
https://www.ncbi.nlm.nih.gov/pubmed/27689338
http://dx.doi.org/10.18632/oncotarget.12332

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