Cargando…

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation

Colorectal cancer (CRC) is the second most common cause of cancer-related death, encouraging the search for novel therapeutic targets affecting tumor cell proliferation and migration. These cellular processes are under tight control of two opposing groups of enzymes; kinases and phosphatases. Aberra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoekstra, Elmer, Das, Asha M., Willemsen, Marcella, Swets, Marloes, Kuppen, Peter J.K., van der Woude, Christien J., Bruno, Marco J., Shah, Jigisha P., Hagen, Timo L.M. ten, Chisholm, John D., Kerr, William G., Peppelenbosch, Maikel P., Fuhler, Gwenny M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341996/ https://www.ncbi.nlm.nih.gov/pubmed/27716613 http://dx.doi.org/10.18632/oncotarget.12321

Ejemplares similares

Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome
por: Hoekstra, Elmer, et al.
Publicado: (2016)

Analysis of SHIP1 expression and activity in Crohn’s disease patients
por: Somasundaram, Rajesh, et al.
Publicado: (2017)

Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer
por: Hoekstra, Elmer, et al.
Publicado: (2015)

Cannabinoid Signal Transduction Explains Disconnect of Cannabis Effects in Experimental and Clinical Colitis
por: Peppelenbosch, Maikel P, et al.
Publicado: (2019)

A Direct Effect of Sex Hormones on Epithelial Barrier Function in Inflammatory Bowel Disease Models
por: van der Giessen, Janine, et al.
Publicado: (2019)

Drug Discovery in Liver Disease Using Kinome Profiling
por: Yu, Bingting, et al.
Publicado: (2021)

Overlapping cytokines in H. pylori infection and gastric cancer: A tandem meta-analysis
por: Yu, Bingting, et al.
Publicado: (2023)

Vedolizumab Tissue Concentration Correlates to Mucosal Inflammation and Objective Treatment Response in Inflammatory Bowel Disease
por: Pauwels, Renske W M, et al.
Publicado: (2021)

Peripheral Neutrophil Functions and Cell Signalling in Crohn`s Disease
por: Somasundaram, Rajesh, et al.
Publicado: (2013)

Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma
por: Wang, Wenhui, et al.
Publicado: (2016)

Ustekinumab Tissue and Serum Levels in Patients With Crohn’s Disease Are Closely Correlated Though Not Consistently Associated With Objective Response After Induction
por: Proietti, Elisa, et al.
Publicado: (2022)

Modulation of cytokine patterns and microbiome during pregnancy in IBD
por: van der Giessen, Janine, et al.
Publicado: (2020)

Platelets in aging and cancer—“double-edged sword”
por: Faria, Alessandra V. S., et al.
Publicado: (2020)

Colorectal Cancer Cell-Derived Small Extracellular Vesicles Educate Human Fibroblasts to Stimulate Migratory Capacity
por: Clerici, Stefano Piatto, et al.
Publicado: (2021)

Pancreatic cyst fluid harbors a unique microbiome
por: Li, Shan, et al.
Publicado: (2017)

Size and Concentration of Extracellular Vesicles in Pancreatic Juice From Patients With Pancreatic Ductal Adenocarcinoma
por: Nesteruk, Kateryna, et al.
Publicado: (2022)

Low dose Naltrexone for induction of remission in inflammatory bowel disease patients
por: Lie, Mitchell R. K. L., et al.
Publicado: (2018)

Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification
por: Lieshout, Ruby, et al.
Publicado: (2022)

Technical challenges regarding the use of formalin-fixed paraffin embedded (FFPE) tissue specimens for the detection of bacterial alterations in colorectal cancer
por: Lam, Suk Yee, et al.
Publicado: (2021)

Depletion of Saccharomyces cerevisiae in psoriasis patients, restored by Dimethylfumarate therapy (DMF)
por: Eppinga, Hester, et al.
Publicado: (2017)

Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots
por: Scholma, Jetse, et al.
Publicado: (2016)

Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids
por: Utomo, Wesley K., et al.
Publicado: (2017)

First steps towards combining faecal immunochemical testing with the gut microbiome in colorectal cancer screening
por: Grobbee, Esmée J, et al.
Publicado: (2019)

Targeting SHIP1 and SHIP2 in Cancer
por: Pedicone, Chiara, et al.
Publicado: (2021)

Biotech-Educated Platelets: Beyond Tissue Regeneration 2.0
por: Andrade, Sheila Siqueira, et al.
Publicado: (2020)

Human mesenchymal stromal cells in adhesion to cell‐derived extracellular matrix and titanium: Comparative kinome profile analysis
por: Baroncelli, Marta, et al.
Publicado: (2018)

Modulation of Indoleamine 2,3-Dioxygenase 1 During Inflammatory Bowel Disease Activity in Humans and Mice
por: Proietti, Elisa, et al.
Publicado: (2023)

N1-Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents
por: Fernandes, Sandra, et al.
Publicado: (2022)

Mutation Analysis of Pancreatic Juice and Plasma for the Detection of Pancreatic Cancer
por: Levink, Iris J. M., et al.
Publicado: (2023)

Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease
por: Nuij, V. J. A. A., et al.
Publicado: (2017)

Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients
por: Faria, Alessandra V. S., et al.
Publicado: (2019)

Correction: Faria, A.V.S. et al., Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients. J. Clin. Med. 2019, 8, 936
por: Faria, Alessandra V. S., et al.
Publicado: (2020)

The Immunogenicity of Colorectal Cancer in Relation to Tumor Development and Treatment
por: de Vries, Natasja L., et al.
Publicado: (2016)

Recurrence of primary sclerosing cholangitis after liver transplantation is associated with specific changes in the gut microbiome pretransplant – a pilot study
por: Visseren, Thijmen, et al.
Publicado: (2020)

6-Thioguanine inhibits rotavirus replication through suppression of Rac1 GDP/GTP cycling
por: Yin, Yuebang, et al.
Publicado: (2018)

Modulatory Effects of Pregnancy on Inflammatory Bowel Disease
por: van der Giessen, Janine, et al.
Publicado: (2019)

Cytopathological Analysis of Cyst Fluid Enhances Diagnostic Accuracy of Mucinous Pancreatic Cystic Neoplasms
por: Utomo, Wesley K., et al.
Publicado: (2015)

Neoantigen Quantity and Quality in Relation to Pancreatic Cancer Survival
por: Levink, Iris J. M., et al.
Publicado: (2022)

Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV
por: Wang, Wenshi, et al.
Publicado: (2016)

PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex
por: Alves, Maria M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_sm0l82og01nefnj5hlqtftfg3h