Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma

Two genes are called synthetic lethal (SL) if their simultaneous mutation leads to cell death, but mutation of either individual does not. Targeting SL partners of mutated cancer genes can selectively kill cancer cells, but leave normal cells intact. We present an integrated approach to uncover SL g...

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Detalles Bibliográficos
Autores principales: Chang, Jan-Gowth, Chen, Chia-Cheng, Wu, Yi-Ying, Che, Ting-Fang, Huang, Yi-Syuan, Yeh, Kun-Tu, Shieh, Grace S., Yang, Pan-Chyr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342006/
https://www.ncbi.nlm.nih.gov/pubmed/27655641
http://dx.doi.org/10.18632/oncotarget.12046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342006/
https://www.ncbi.nlm.nih.gov/pubmed/27655641
http://dx.doi.org/10.18632/oncotarget.12046

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