CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network

Patients with oncogene driven tumors are treated with targeted therapeutics including EGFR inhibitors. Genomic data from The Cancer Genome Atlas (TCGA) demonstrates molecular alterations to EGFR, MAPK, and PI3K pathways in previously untreated tumors. Therefore, this study uses bioinformatics algori...

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Detalles Bibliográficos
Autores principales: Fertig, Elana J., Ozawa, Hiroyuki, Thakar, Manjusha, Howard, Jason D., Kagohara, Luciane T., Krigsfeld, Gabriel, Ranaweera, Ruchira S., Hughes, Robert M., Perez, Jimena, Jones, Siân, Favorov, Alexander V., Carey, Jacob, Stein-O'Brien, Genevieve, Gaykalova, Daria A., Ochs, Michael F., Chung, Christine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342018/
https://www.ncbi.nlm.nih.gov/pubmed/27650546
http://dx.doi.org/10.18632/oncotarget.12075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342018/
https://www.ncbi.nlm.nih.gov/pubmed/27650546
http://dx.doi.org/10.18632/oncotarget.12075

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