Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

Mitochondrial DNA mutations and defects in mitochondrial enzymes have been identified in gastric cancers, and they might contribute to cancer progression. In previous studies, mitochondrial dysfunction was induced by oligomycin-enhanced chemoresistance to cisplatin. Herein, we dissected the regulato...

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Detalles Bibliográficos
Autores principales: Wang, Sheng-Fan, Chen, Meng-Shian, Chou, Yueh-Ching, Ueng, Yune-Fang, Yin, Pen-Hui, Yeh, Tien-Shun, Lee, Hsin-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342041/
https://www.ncbi.nlm.nih.gov/pubmed/27708226
http://dx.doi.org/10.18632/oncotarget.12356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342041/
https://www.ncbi.nlm.nih.gov/pubmed/27708226
http://dx.doi.org/10.18632/oncotarget.12356

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