Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. Loss of p53 function in CLL cells due to chromosome 17p deletion or p53 mutations often leads to a more malignant disease phenotype and is associated with drug resistance and poor clinical outcome. Thus, devel...

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Detalles Bibliográficos
Autores principales: Liu, Jinyun, Chen, Gang, Pelicano, Helene, Liao, Jianwei, Huang, Jie, Feng, Li, Keating, Michael J., Huang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342085/
https://www.ncbi.nlm.nih.gov/pubmed/27655686
http://dx.doi.org/10.18632/oncotarget.12110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342085/
https://www.ncbi.nlm.nih.gov/pubmed/27655686
http://dx.doi.org/10.18632/oncotarget.12110

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