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Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. Loss of p53 function in CLL cells due to chromosome 17p deletion or p53 mutations often leads to a more malignant disease phenotype and is associated with drug resistance and poor clinical outcome. Thus, devel...
Autores principales: | Liu, Jinyun, Chen, Gang, Pelicano, Helene, Liao, Jianwei, Huang, Jie, Feng, Li, Keating, Michael J., Huang, Peng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342085/ https://www.ncbi.nlm.nih.gov/pubmed/27655686 http://dx.doi.org/10.18632/oncotarget.12110 |
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