Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells

Anti-estrogen treatment, exemplified by tamoxifen, is a well-established adjuvant therapy for estrogen receptor alpha (ERα)-positive breast cancer. However, the effectiveness of this drug is limited due to the development of resistance. The Hedgehog (HH) signaling pathway is critical in embryonic de...

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Detalles Bibliográficos
Autores principales: Diao, Yumei, Azatyan, Ani, Rahman, Mohammed Ferdous-Ur, Zhao, Chunyan, Zhu, Jian, Dahlman-Wright, Karin, Zaphiropoulos, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342103/
https://www.ncbi.nlm.nih.gov/pubmed/27689403
http://dx.doi.org/10.18632/oncotarget.12259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342103/
https://www.ncbi.nlm.nih.gov/pubmed/27689403
http://dx.doi.org/10.18632/oncotarget.12259

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