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Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells

Anti-estrogen treatment, exemplified by tamoxifen, is a well-established adjuvant therapy for estrogen receptor alpha (ERα)-positive breast cancer. However, the effectiveness of this drug is limited due to the development of resistance. The Hedgehog (HH) signaling pathway is critical in embryonic de...

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Detalles Bibliográficos
Autores principales:	Diao, Yumei, Azatyan, Ani, Rahman, Mohammed Ferdous-Ur, Zhao, Chunyan, Zhu, Jian, Dahlman-Wright, Karin, Zaphiropoulos, Peter G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342103/ https://www.ncbi.nlm.nih.gov/pubmed/27689403 http://dx.doi.org/10.18632/oncotarget.12259

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