Cargando…
MDS shows a higher expression of hTERT and alternative splice variants in unactivated T-cells
Telomere instability and telomerase reactivation are believed to play an important role in the development of myelodysplastic syndromes (MDS). Abnormal enzymatic activity of human telomerase reverse transcriptase (hTERT), and its alternative splice variants have been reported to account for deregula...
Autores principales: | Dong, Wen, Wu, Lei, Sun, Houfang, Ren, Xiubao, Epling-Burnette, Pearlie K., Yang, Lili |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342131/ https://www.ncbi.nlm.nih.gov/pubmed/27655690 http://dx.doi.org/10.18632/oncotarget.12115 |
Ejemplares similares
-
Naïve T-cells in Myelodysplastic Syndrome Display Intrinsic Human Telomerase Reverse Transcriptase (hTERT) Deficiency
por: Yang, Lili, et al.
Publicado: (2012) -
Insights into Telomerase/hTERT Alternative Splicing Regulation Using Bioinformatics and Network Analysis in Cancer
por: Ludlow, Andrew T., et al.
Publicado: (2019) -
The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
por: Slusher, Aaron L., et al.
Publicado: (2020) -
Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity
por: Liu, Xuewen, et al.
Publicado: (2017) -
Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)