Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity

ICAT (Inhibitor of β-CAtenin and TCF) is a small acidic protein that negatively regulates β-catenin co-transcriptional activity by competing with TCF/LEF factors in their binding to β-catenin superhelical core. In melanoma cells, ICAT competes with LEF1 to negatively regulate the M-MITF and NEDD9 ta...

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Detalles Bibliográficos
Autores principales: Domingues, Mélanie J., Martinez-Sanz, Juan, Papon, Laura, Larue, Lionel, Mouawad, Liliane, Bonaventure, Jacky
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342195/
https://www.ncbi.nlm.nih.gov/pubmed/28273108
http://dx.doi.org/10.1371/journal.pone.0172603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342195/
https://www.ncbi.nlm.nih.gov/pubmed/28273108
http://dx.doi.org/10.1371/journal.pone.0172603

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