Polymer micelle formulation for the proteasome inhibitor drug carfilzomib: Anticancer efficacy and pharmacokinetic studies in mice

Carfilzomib (CFZ) is a peptide epoxyketone proteasome inhibitor approved for the treatment of multiple myeloma (MM). Despite the remarkable efficacy of CFZ against MM, the clinical trials in patients with solid cancers yielded rather disappointing results with minimal clinical benefits. Rapid degrad...

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Detalles Bibliográficos
Autores principales: Park, Ji Eun, Chun, Se-Eun, Reichel, Derek, Min, Jee Sun, Lee, Su-Chan, Han, Songhee, Ryoo, Gongmi, Oh, Yunseok, Park, Shin-Hyung, Ryu, Heon-Min, Kim, Kyung Bo, Lee, Ho-Young, Bae, Soo Kyung, Bae, Younsoo, Lee, Wooin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342227/
https://www.ncbi.nlm.nih.gov/pubmed/28273121
http://dx.doi.org/10.1371/journal.pone.0173247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342227/
https://www.ncbi.nlm.nih.gov/pubmed/28273121
http://dx.doi.org/10.1371/journal.pone.0173247

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