Synthesis, in vitro and in vivo evaluation of 3β-[(18)F]fluorocholic acid for the detection of drug-induced cholestasis in mice

INTRODUCTION: Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development. In this work, Positron Emission Tomography (PET)-imaging with a (18)F la...

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Detalles Bibliográficos
Autores principales: De Lombaerde, Stef, Neyt, Sara, Kersemans, Ken, Verhoeven, Jeroen, Devisscher, Lindsey, Van Vlierberghe, Hans, Vanhove, Christian, De Vos, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342262/
https://www.ncbi.nlm.nih.gov/pubmed/28273180
http://dx.doi.org/10.1371/journal.pone.0173529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342262/
https://www.ncbi.nlm.nih.gov/pubmed/28273180
http://dx.doi.org/10.1371/journal.pone.0173529

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