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Synthesis, in vitro and in vivo evaluation of 3β-[(18)F]fluorocholic acid for the detection of drug-induced cholestasis in mice
INTRODUCTION: Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development. In this work, Positron Emission Tomography (PET)-imaging with a (18)F la...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342262/ https://www.ncbi.nlm.nih.gov/pubmed/28273180 http://dx.doi.org/10.1371/journal.pone.0173529 |