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Gallic acid inhibition of Src-Stat3 signaling overcomes acquired resistance to EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR) have clinically benefited to lung cancer patients harboring a subset of activating EGFR mutations. However, even with the remarkable therapeutic response at the initial TKI treatment, most lung cancer patients eventu...

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Detalles Bibliográficos
Autores principales: Phan, Ai N.H., Hua, Tuyen N.M., Kim, Min-Kyu, Vo, Vu T.A., Choi, Jong-Whan, Kim, Hyun-Won, Rho, Jin Kyung, Kim, Ki Woo, Jeong, Yangsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342374/
https://www.ncbi.nlm.nih.gov/pubmed/27419630
http://dx.doi.org/10.18632/oncotarget.10581