Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells

A poor prognosis subtype of acute myeloid leukemia (AML) is characterized by increased expression of a set of homeodomain (HD) transcription factors, including HoxA9, HoxA10 and Cdx4. This encompasses AML with MLL1 gene translocations, because Mll1-fusion proteins aberrantly activate HOX transcripti...

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Detalles Bibliográficos
Autores principales: Shah, Chirag A., Bei, Ling, Wang, Hao, Altman, Jessica K., Platanias, Leonidas C., Eklund, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342381/
https://www.ncbi.nlm.nih.gov/pubmed/27340869
http://dx.doi.org/10.18632/oncotarget.10189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342381/
https://www.ncbi.nlm.nih.gov/pubmed/27340869
http://dx.doi.org/10.18632/oncotarget.10189

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