FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition

Dual PI3K/mTOR inhibitors do not effectively radiosensitize glioblastoma multiforme stem cells (GBM-SCs), but p53-proficient GBM-SCs are more responsive than p53-deficient ones. Here, we found that p53-proficient, but not p53-deficient, GBM-SCs lost stemness and differentiated after γ-irradiation co...

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Detalles Bibliográficos
Autores principales: Firat, Elke, Niedermann, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342388/
https://www.ncbi.nlm.nih.gov/pubmed/27448972
http://dx.doi.org/10.18632/oncotarget.10702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342388/
https://www.ncbi.nlm.nih.gov/pubmed/27448972
http://dx.doi.org/10.18632/oncotarget.10702

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